4,4'-methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate [1] 2,2'-methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate [2] o-(p-isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate [3] methylenediphenyl diisocyanate [4]
CAS 101-68-8 · C15H10N2O2
Hazard classDanger — Health hazard, Irritant / harmful
PictogramsHealth hazardIrritant / harmful
H-statements- H351 Suspected of causing cancer
- H332 Harmful if inhaled
- H335 May cause respiratory irritation
- H373 May cause damage to organs through prolonged or repeated exposure
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
- H317 May cause an allergic skin reaction
Common uses (US EPA CDR)MonomersAdhesion/cohesion promoterHardenerBinderIntermediateSealant (barrier)
Workplace exposure limitsNIOSH REL TWA 0.05 mg/m3 (0.005 ppm) C 0.2 mg/m3 (0.020 ppm) [10-minute]
OSHA PEL C 0.2 mg/m3 (0.02 ppm)
IDLH 75 mg/m3Occupational exposure limits — NIOSH Pocket Guide.
Synonyms4,4'-Diphenylmethane diisocyanate · Diphenylmethane diisocyanate · Bis(4-isocyanatophenyl)methane · 4,4'-Methylenebis(phenyl isocyanate) · Isonate · Desmodur 44 · p,p'-Diphenylmethane diisocyanate · 1,1'-Methylenebis(4-isocyanatobenzene)
Molecular weight250.25 g/mol
Data sourceHarmonised classification ECHA — EU CLP Annex VILegally binding EU classification adopted by ECHA under CLP Annex VI — the highest-confidence GHS source.
Search the full chemical database →
Guide only. This information is compiled from published safety data sheets and public regulatory registries and is believed correct at the date of publication shown. It is not all-inclusive and shall be used only as a guide. It does not replace the manufacturer’s current Safety Data Sheet, which governs in all cases. SNRL shall not be held liable for any injury, loss or damage resulting from handling of, or contact with, any product listed.